Xiang Luping,Fu Hao,Liu Yuanmei.Applications and research advances of multi-omics for Hirschsprung’s disease[J].Journal of Clinical Pediatric Surgery,2024,(05):434-439.[doi:10.3760/cma.j.cn101785-202312028-007]
多组学在先天性巨结肠中的应用及研究进展
- Title:
- Applications and research advances of multi-omics for Hirschsprung’s disease
- Keywords:
- Hirschsprung Disease; Genomics; Transcriptomics; Proteomics; Surgical Procedures; Operative; Child
- 摘要:
- 先天性巨结肠(Hirschsprung’s disease,HSCR)是由环境、遗传等多因素导致的疾病,手术是其主要治疗手段,其基本病理改变为不同长度的远端肠管神经节缺如。目前已有大量关于HSCR在基因组学、转录组学、蛋白质组学等方面的研究报道,多组学在HSCR的筛查、诊断以及发病机制探索中发挥了重要作用。本文就多组学技术在HSCR中的应用与研究进展进行综述。
- Abstract:
- Hirschsprung’s disease (HSCR) is a disease caused by both environmental and genetic factors.And surgical intervention has remained a major treatment.Its basic pathological changes include an absence of distal intestinal ganglia of varying lengths,abdominal distension and constipation.Currently a large number of studies have been devoted to HSCR in genomics,transcriptomics,proteomics and other multi-omics.Multi-omic has played an important role in the screening,diagnosis and pathogenesis of HSCR.This review focused upon the latest applications and researches of multi-omics technology for HSCR.
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备注/Memo
收稿日期:2023-12-12。
基金项目:国家自然科学基金(82060100)
通讯作者:刘远梅, Email:yuanmei116@aliyun.com