Shi Shengkun,Yang Yi.Research advances on risk factors and preventions of renal scar associated with primary vesicoureteral reflux[J].Journal of Clinical Pediatric Surgery,2023,22(10):937-943.[doi:10.3760/cma.j.cn101785-202305011-007]
原发性膀胱输尿管反流患儿肾瘢痕发生风险因素及预防的研究进展
- Title:
- Research advances on risk factors and preventions of renal scar associated with primary vesicoureteral reflux
- 摘要:
- 膀胱输尿管反流(vesicoureteral reflux,VUR)是小儿常见的泌尿系统异常,受到国内外学者的广泛关注,特别是VUR导致的不可逆性肾瘢痕,国内外对其危险因素以及预防措施的研究颇多,尤其是2007年膀胱输尿管反流随机化干预(randomized intervention for children with vesicoureteral reflux,RIVUR)试验结束后,相关试验与统计研究的结果相继发表,在评估预防性口服抗生素对于初次泌尿道感染(urinary tract infection,UTI)后诊断VUR儿童的治疗有效性,以及VUR患儿肾瘢痕形成的危险因素等方面,提出了新的观点与思考。本文就VUR导致肾瘢痕发生的危险因素,以及预防性口服抗生素治疗的研究进展进行综述。
- Abstract:
- As a common urinary system anomaly in children,vesicoureteral reflux (VUR) has attracted growing attention from scholars at both home and abroad.A particular focus is irreversible renal scar of VUR.Numerous studies have examined its risk factors and preventive measures.After the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial in 2007,the results of relevant trials and statistical studies have been published successively.New concepts have been proposed for evaluating the therapeutic effectiveness of oral prophylactic antibiotics after primary urinary tract infection (UTI) and the risk factors for renal scarring in VUR children.This review summarized the risk factors of renal scarring due to primary VUR and the latest researches of oral prophylactic antibiotic therapy.
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备注/Memo
收稿日期:2023-5-8。
基金项目:辽宁省教育厅基本科研项目(LJKMZ20221180);辽宁省重点研发计划联合计划项目(2020JH2/10300145)
通讯作者:杨屹,Email:yangy2@sj-hospital.org