Yang Shaobo,Zhao Jie.Nodular sclerosis with subependymal giant cell astrocytoma:a report of two cases with a literature review[J].Journal of Clinical Pediatric Surgery,2023,22(05):476-479.[doi:10.3760/cma.j.cn101785-202202001-014]
结节性硬化合并室管膜下巨细胞星形细胞瘤2例及文献复习
- Title:
- Nodular sclerosis with subependymal giant cell astrocytoma:a report of two cases with a literature review
- 摘要:
- 结节性硬化症(tuberous sclerosis,TS)是一种常染色体显性遗传病,以纤维血管瘤和不同器官(主要是中枢神经系统)的多发性肿瘤为特征。TS患儿存在3种类型的脑部病变:皮质结节、室管膜下结节和室管膜下巨细胞星形细胞瘤(subependymal giant cell astrocytoma,SEGA)。本文报道的2例SEGA患儿病灶位于脑室体部孟氏孔附近,术后均经病理检查证实为SEGA;2例免疫组织化学检测结果:GFAP(+),Olig2(-),Ki67 1%(+)。肿瘤均完整切除,术后随访至今均无癫痫发作,预后良好。
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备注/Memo
收稿日期:2021-6-11。
通讯作者:赵杰,Email:zhao1976jie@126.com