Yang Zhenzhen,Li Jiayi,Liu Pei,et al.Efficacy of one-stage Duckett versus staged Bracka urethroplasty for nondistal hypospadias: a meta-analysis[J].Journal of Clinical Pediatric Surgery,2023,22(02):168-179.[doi:10.3760/cma.j.cn101785-202202018-014]
一期Duckett与分期Bracka尿道成形术治疗非远端型尿道下裂术后并发症的Meta分析
- Title:
- Efficacy of one-stage Duckett versus staged Bracka urethroplasty for nondistal hypospadias: a meta-analysis
- 摘要:
- 目的 评价并比较一期Duckett与分期Bracka尿道成形术治疗非远端型尿道下裂的临床疗效。 方法 检索PubMed、Embase、Web of science、Cochrane图书馆、中国知网、万方和维普数据库中关于一期Duckett与分期Bracka尿道成形术治疗非远端型尿道下裂的随机或非随机对照试验、队列研究和病例对照研究,检索文献时限为数据库建库至2022年3月28日。结局指标包括术后总体并发症和独立并发症(尿道瘘、尿道狭窄、尿道憩室、伤口裂开及移植物相关并发症)情况及手术次数。应用RevMan 5.4进行Meta分析。 结果 本研究共纳入41篇文献共3 713例患儿,其中2 395例接受一期Duckett尿道成形术,1 318例接受分期Bracka尿道成形术。Meta分析结果显示,一期Duckett尿道成形术较分期Bracka尿道成形术,术后尿道瘘(RD=0.17和RD=0.10,P<0.05)、尿道狭窄(RD=0.10与RD=0.03,P<0.05)及尿道憩室(RD=0.04与RD=0.02,P<0.05)的发生率均更高,差异均有统计学意义。5篇关于两种术式对比研究的Meta分析结果显示,一期Duckett尿道成形术后总并发症发生率高于分期Brack尿道成形术(OR=2.63,95%CI:1.54~4.50,P< 0.05)。一期Duckett尿道成形术与分期Bracka尿道成形术平均手术次数分别为1.29次和2.15次。 结论 一期Duckett尿道成形术后并发症总发生率,尿道瘘、尿道狭窄及尿道憩室发生率高于分期Bracka尿道成形术;分期Bracka尿道成形术后移植物相关并发症发生率为5%。一期Duckett尿道成形术治愈非远端型尿道下裂所需手术次数更少。
- Abstract:
- Objective To review the currently available data and evaluate the efficacy of one-stage Duckett versus staged Bracka urethroplasty for non-distal hypospadias through Meta-analysis.Methods The database of PubMed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang and VIP were searched for randomized or non-randomized controlled trials,cohort studies and case-control studies of one-stage Duckett versus staged Bracka urethroplasty for non-distal hypospadias.The measurement parameters included overall postoperative complications and individual complications(urethral fistula,urethral stricture,urethral diverticulum,wound dehiscence & graft-related complications).Meta-analysis was performed with RevMan 5.4 software.Results A total of 3 713 children were collected from 41 articles examining the effectiveness of one-stage Duckett urethroplasty(n=2 395)versus staged Bracka urethroplasty(n=1 318)were included for Meta-analysis.Meta-analysis results indicated that marked inter-group differences existed in occurrence rate of postoperative urethral fistula(RD=0.17 and RD=0.10,P<0.05),occurrence rate of urethral stricture(RD=0.10 and RD=0.03,P<0.05),occurrence rate of diverticula(RD=0.04 and RD=0.02,P<0.05)and occurrence rate of postoperative wound dehiscence(RD=0.02 and RD=0.04,P<0.05).Meta-analysis results of 5 comparative studies showed that total complication rate after one-stage Duckett urethroplasty was higher than that of staged Brack(OR=2.63,95%CI:1.54-4.50,P<0.05).Operative frequency of one-stage Duckett urethroplasty and staged bracka urethroplasty were 1.29 and 2.15 respectively.Conclusion The occurrence rate of total complications,urethral fistula,urethral stricture and urethral diverticulum after one-stage Duckett urethroplasty was higher than that of staged Bracka.Graft-related complication rate after staged Bracka urethroplasty is 5%.One-stage Duckett urethroplasty for non-distal hypospadias requires fewer operations.
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备注/Memo
收稿日期:2022-5-5。
通讯作者:张潍平,Email:zhangwpp@163.com