Wang Jianfeng,Zhu Hui,Chen Jie.Recent advances in gastrointestinal interstitial cells regulating colonic motility[J].Journal of Clinical Pediatric Surgery,2022,21(12):1191-1196.[doi:10.3760/cma.j.cn101785-202010023-017]
肠道间质细胞参与调控结肠动力的研究进展
- Title:
- Recent advances in gastrointestinal interstitial cells regulating colonic motility
- Keywords:
- Colon; Pathology; Surgical; Stromal Cells; Physiology; Enteric Nervous System; Hirschsprung Disease; Etiology
- 摘要:
- 肠道间质细胞是起源于间胚层、非神经非胶质细胞的一类特殊细胞,分布于消化道管壁各层。消化道平滑肌层内存在两种间质细胞,包括Cajal间质细胞(interstitial cell of Cajal,ICC)和PDGFRα+细胞(platelet growth factor receptor positive cells,PDGFRα+cells),在消化道平滑肌动力调控中起着重要的作用,并与消化道动力障碍性疾病有着密切关系。近年来,随着SIP合胞体(smooth muscle cell,interstitial cell of Cajal and PDGFRα+ cell syncytium,SIP syncytium)概念的提出,PDGFRα+细胞成为结肠动力机制研究中人们关注的焦点之一,为结肠传输功能障碍性疾病的机制研究提供了新的思路。本文综述肠道间质细胞,尤其是PDGFRα+细胞在结肠传输障碍中的作用机制及其在先天性巨结肠中的研究进展。
- Abstract:
- Interstitial cells of Cajal (ICCs) and platelet-derived growth factor receptor alpha positive cells (PDGFR α+ cells) are distributed between autonomic nerve endings of digestive tract and smooth muscle cells.Both play an important role in the regulation of smooth muscle cells (SMCs) motility of digestive tract and closely correlated with gastrointestinal motility disorders (GMDs).In recent years,with the introduction of a new concept of SIP,PDGFRα+ cells have gradually become the focal point of colonic motility mechanism,bringing new ideas to the mechanistic study of colonic transit dysfunction diseases.This review summarized the research advances of intestitinal cells,especially PDGFRα+ cells in mechanism of colonic motility disorders and Hirschsprung disease (HSCR).
参考文献/References:
[1] Furness JB.The enteric nervous system and neurogastroenterology[J].Nat Rev Gastroenterol Hepatol,2012,9(5):286-294.DOI:10.1038/nrgastro.2012.32.
[2] Furness JB.Integrated neural and endocrine control of gastrointestinal function[J].Adv Exp Med Biol,2016,891:159-173.DOI:10.1007/978-3-319-27592-5_16.
[3] Fida R,Lyster DJ,Bywater RA,et al.Colonic migrating motor complexes (CMMCs) in the isolated mouse colon[J].Neurogastroenterol Motil,1997,9(2):99-107.DOI:10.1046/j.1365-2982.1997.d01-25.x.
[4] Costa M,Brookes SJ,Hennig GW.Anatomy and physiology of the enteric nervous system[J].Gut,2000,47(Suppl 4):iv15-iv19.DOI:10.1136/gut.47.suppl_4.iv15.
[5] Brehmer A.Structure of enteric neurons[J].Adv Anat Embryol Cell Biol,2006,186:1-91.
[6] Yntema CL,Hammond WS.The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo[J].J Comp Neurol,1954,101(2):515-541.DOI:10.1002/cne.901010212.
[7] Burns AJ,Le Douarin NM.Enteric nervous system development:analysis of the selective developmental potentialities of vagal and sacral neural crest cells using quail-chick chimeras[J].Anat Rec,2001,262(1):16-28.DOI:10.1002/1097-0185 (20010101)262:1＜16::AID-AR1007＞3.0.CO;2-O.
[8] Anderson RB,Stewart AL,Young HM.Phenotypes of neural-crest-derived cells in vagal and sacral pathways[J].Cell Tissue Res,2006,323(1):11-25.DOI:10.1007/s00441-005-0047-6.
[9] Nagy N,Burns AJ,Goldstein AM.Immunophenotypic characterization of enteric neural crest cells in the developing avian colorectum[J].Dev Dyn,2012,241(5):842-851.DOI:10.1002/dvdy.23767.
[10] McCann CJ,Alves MM,Brosens E,et al.Neuronal development and onset of electrical activity in the human enteric nervous system[J].Gastroenterology,2019,156(5):1483-1495.e6.DOI:10.1053/j.gastro.2018.12.020.
[11] Fu M,Lui VC,Sham MH,et al.HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts[J].Dev Dyn,2003,228(1):1-10.DOI:10.1002/dvdy.10350.
[12] Young HM,Jones BR,McKeown SJ.The projections of early enteric neurons are influenced by the direction of neural crest cell migration[J].J Neurosci,2002,22(14):6005-6018.DOI:10.1523/JNEUROSCI.22-14-06005.2002.
[13] Hao MM,Boesmans W,Van den Abbeel V,et al.Early emergence of neural activity in the developing mouse enteric nervous system[J].J Neurosci,2011,31(43):15352-15361.DOI:10.1523/JNEUROSCI.3053-11.2011.
[14] Spencer NJ,Hu H.Enteric nervous system:sensory transduction,neural circuits and gastrointestinal motility[J].Nat Rev Gastroenterol Hepatol,2020,17(6):338-351.DOI:10.1038/s41575-020-0271-2.
[15] Blair PJ,Rhee PL,Sanders KM,et al.The significance of interstitial cells in neurogastroenterology[J].J Neurogastroenterol Motil,2014,20(3):294-317.DOI:10.5056/jnm14060.
[16] Drumm BT,Hwang SJ,Baker SA,et al.Ca(2+) signaling behaviours of intramuscular interstitial cells of Cajal in the murine colon[J].J Physiol,2019,597(14):3587-3617.DOI:10.1113/JP278036.
[17] Yang S,Dong F,Li D,et al.Persistent distention of colon damages interstitial cells of Cajal through Ca(2+) -ERK-AP-1-miR-34c-SCF deregulation[J].J Cell Mol Med,2017,21(9):1881-1892.DOI:10.1111/jcmm.13108.
[18] Jitariu AA,Cimpean AM,Kundnani NR,et al.Platelet-derived growth factors induced lymphangiogenesis:evidence,unanswered questions and upcoming challenges[J].Arch Med Sci,2015,11(1):57-66.DOI:10.5114/aoms.2015.49217.
[19] Gouveia L,Betsholtz C,Andrae J.Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung[J].Physiol Rep,2017,5(6):e13092.DOI:10.14814/phy2.13092.
[20] Iino S,Horiguchi K,Horiguchi S,et al.c-Kit-negative fibroblast-like cells express platelet-derived growth factor receptor alpha in the murine gastrointestinal musculature[J].Histochem Cell Biol,2009,131(6):691-702.DOI:10.1007/s00418-009-0580-6.
[21] Kurahashi M,Zheng H,Dwyer L,et al.A functional role for the ’fibroblast-like cells’ in gastrointestinal smooth muscles[J].J Physiol,2011,589(Pt 3):697-710.DOI:10.1113/jphysiol.2010.201129.
[22] Mitsui R,Komuro T.Direct and indirect innervation of smooth muscle cells of rat stomach,with special reference to the interstitial cells of Cajal[J].Cell Tissue Res,2002,309(2):219-227.DOI:10.1007/s00441-002-0592-1.
[23] Koh SD,Ward SM,Sanders KM.Ionic conductances regulating the excitability of colonic smooth muscles[J].Neurogastroenterol Motil,2012,24(8):705-718.DOI:10.1111/j.1365-2982.2012.01956.x.
[24] Sanders KM,Ward SM,Koh SD.Interstitial cells:regulators of smooth muscle function[J].Physiol Rev,2014,94(3):859-907.DOI:10.1152/physrev.00037.2013.
[25] Sung TS,Kim HU,Kim JH,et al.Protease-activated receptors modulate excitability of murine colonic smooth muscles by differential effects on interstitial cells[J].J Physiol,2015,593(5):1169-1181.DOI:10.1113/jphysiol.2014.285148.
[26] Ha SE,Lee MY,Kurahashi M,et al.Transcriptome analysis of PDGFR α+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia[J].PLoS One,2017,12(8):e0182265.DOI:10.1371/journal.pone.0182265.
[27] Durnin L,Lees A,Manzoor S,et al.Loss of nitric oxide-mediated inhibition of purine neurotransmitter release in the colon in the absence of interstitial cells of Cajal[J].Am J Physiol Gastrointest Liver Physiol,2017,313(5):G419-G433.DOI:10.1152/ajpgi.00045.2017.
[28] 宋妮娜,许文燮.胃肠平滑肌运动单位SIP合胞体的生理与病理生理学意义[J].生理学报,2016,68(5):621-627.DOI:10.13294/j.aps.2016.0073.
Song NN,Xu WX.Physiological and pathophysiological significance of gastrointestinal smooth muscle motor unit SIP syncytium[J].Acta Physiologica Sinica,2016,68(5):621-627.DOI:10.13294/j.aps.2016.0073.
[29] Kurahashi M,Kito Y,Baker SA,et al.A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility[J].FASEB J,2020,34(4):5563-5577.DOI:10.1096/fj.201903134R.
[30] Lu C,Huang X,Lu HL,et al.Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice[J].World J Gastroenterol,2018,24(44):4989-5004.DOI:10.3748/wjg.v24.i44.4989.
[31] Wang Q,Zang J,Huang X,et al.Colonic dysmotility in murine partial colonic obstruction due to functional changes in interstitial cells[J].J Neurogastroenterol Motil,2019,25(4):589-601.DOI:10.5056/jnm19136.
[32] Peri LE,Sanders KM,Mutafova-Yambolieva VN.Differential expression of genes related to purinergic signaling in smooth muscle cells,PDGFRα-positive cells,and interstitial cells of Cajal in the murine colon[J].Neurogastroenterol Motil,2013,25(9):e609-e620.DOI:10.1111/nmo.12174.
[33] Benninga MA,Faure C,Hyman PE,et al.Childhood functional gastrointestinal disorders:neonate/toddler[J].Gastroenterology,2016,S0016-5085(16)00182-7.DOI:10.1053/j.gastro.2016.02.016.
[34] Ranasinghe N,Devanarayana NM,Benninga MA,et al.Psychological maladjustment and quality of life in adolescents with constipation[J].Arch Dis Child,2017,102(3):268-273.DOI:10.1136/archdischild-2016-310694.
[35] Jeffrey HS,Cario DL,Miguel S,et al.Functional disorders:children and adolescents[J].Gastroenterology,2016,150:1456-1468.DOI:10.1053/j.gastro.2016.02.015.
[36] Tam P,Chung P,St Peter SD,et al.Advances in paediatric gastroenterology[J].Lancet,2017,390(10099):1072-1082.DOI:10.1016/S0140-6736(17)32284-5.
[37] Coyle D,O’Donnell AM,Gillick J,et al.Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung’s disease[J].J Pediatr Surg,2016,51(5):762-769.DOI:10.1016/j.jpedsurg.2016.02.018.
[38] Kobayashi H,O’Briain DS,Puri P.Lack of expression of NADPH-diaphorase and neural cell adhesion molecule (NCAM) in colonic muscle of patients with Hirschsprung’s disease[J].J Pediatr Surg,1994,29(2):301-304.DOI:10.1016/0022-3468(94)90336-0.
[39] Larsson LT,Shen Z,Ekblad E,et al.Lack of neuronal nitric oxide synthase in nerve fibers of aganglionic intestine:a clue to Hirschsprung’s disease[J].J Pediatr Gastroenterol Nutr,1995,20(1):49-53.DOI:10.1097/00005176-199501000-00009.
[40] Hanani M,Louzon V,Udassin R,et al.Nitric oxide-containing nerves in bowel segments of patients with Hirschsprung’s disease[J].J Pediatr Surg,1995,30(6):818-822.DOI:10.1016/0022-3468(95)90756-4.
[41] O’Donnell AM,Puri P.Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung’s disease[J].Pediatr Surg Int,2008,24(1):77-80.DOI:10.1007/s00383-007-2044-1.
[42] Coyle D,Danielle AMK,O’Donnell AM,et al.Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease[J].Pediatr Surg Int,2016,32(2):125-133.DOI:10.1007/s00383-015-3822-9.
[43] Cheng LS,Schwartz DM,Hotta R,et al.Bowel dysfunction following pullthrough surgery is associated with an overabundance of nitrergic neurons in Hirschsprung disease[J].J Pediatr Surg,2016,51(11):1834-1838.DOI:10.1016/j.jpedsurg.2016.08.001.
[44] Piotrowska AP,Solari V,Puri P.Distribution of Ca2+-activated K channels,SK2 and SK3,in the normal and Hirschsprung’s disease bowel[J].J Pediatr Surg,2003,38(6):978-983.DOI:10.1016/s0022-3468(03)00138-6.
[45] Coyle D,O’Donnell AM,Puri P.Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirsch-sprung’s disease[J].J Pediatr Surg,2015,50(10):1659-1664.DOI:10.1016/j.jpedsurg.2015.01.013.
[46] O’Donnell AM,Coyle D,Puri P.Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung’s disease colon[J].World J Gastroenterol,2016,22(12):3335-3340.DOI:10.3748/wjg.v22.i12.3335.
[47] Jarvi K,Laitakari EM,Koivusalo A,et al.Bowel function and gastrointestinal quality of life among adults operated for Hirschsprung disease during childhood:a population-based study[J].Ann Surg,2010,252(6):977-981.DOI:10.1097/SLA.0b013e3182018542.
[48] Neuvonen MI,Kyrklund K,Rintala RJ,et al.Bowel function and quality of life after transanal endorectal pull-through for Hirschsprung disease:controlled outcomes up to adulthood[J].Ann Surg,2017,265(3):622-629.DOI:10.1097/SLA.0000000000001695.
[49] Bj?rnland K,Pakarinen MP,Stenstr?m P,et al.A Nordic multicenter survey of long-term bowel function after transanal endorectal pull-through in 200 patients with rectosigmoid Hirschsprung disease[J].J Pediatr Surg,2017,52(9):1458-1464.DOI:10.1016/j.jpedsurg.2017.01.001.
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备注/Memo
收稿日期:2020-10-26。
基金项目:上海市卫生健康委员会卫生行业临床研究专项计划(201940508); 浙江省医药卫生科技 计划项目(2022KY390,2022RC271)
通讯作者:陈杰,Email:jiechen1974@163.com