[1]王俊,施诚仁.重视出生结构缺陷的早期干预 发展母胎医学[J].临床小儿外科杂志,2022,21(09):801-804.[doi:10.3760/cma.j.cn101785-202208026-001]
　Wang Jun,Shi Chenren.Emphasis on early intervention of fetal structural defects and developing of maternal-fetal medicine[J].Journal of Clinical Pediatric Surgery,2022,21(09):801-804.[doi:10.3760/cma.j.cn101785-202208026-001]
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重视出生结构缺陷的早期干预 发展母胎医学

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 第21卷 期数: 2022年09期 页码: 801-804 栏目: 述评 出版日期: 2022-09-28
Title:
Emphasis on early intervention of fetal structural defects and developing of maternal-fetal medicine
作者:
王俊;  施诚仁
上海交通大学医学院附属新华医院, 上海 200092
Author(s):
Wang Jun;  Shi Chenren
Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
关键词:
畸形; 严重畸胎样/外科学; 婴儿; 新生; 产前诊断/仪器和设备; 胎儿期疗法
Keywords:
Abnormalities;  Severe Teratoid/SU; Infant;  Newborn; Prenatal Diagnosis/IS; Fetal Therapies
DOI:
10.3760/cma.j.cn101785-202208026-001
摘要:
出生结构缺陷是导致婴幼儿死亡和先天残疾的主要原因。随着对出生结构缺陷认识的不断深入，以及各种产前诊断方法的进步，一些出生结构缺陷在产前便可获得诊断。随着“母胎医学”的发展，部分出生结构缺陷可在胎儿期通过手术干预治疗得到及早矫治，从而改善患儿预后，提高生命质量。目前，国内母胎医学和胎儿期手术干预治疗技术尚处于起步阶段，对于出生结构缺陷的诊治尚存在认识差异。本文就出生结构缺陷流行病学、母胎医学的兴起和发展以及胎儿期外科手术干预治疗的相关内容进行阐述，以期为临床开展相关工作提供参考。
Abstract:
Fetal structural defects are the leading cause of death and congenital disability in infants and toddlers children.With the deeper understanding of fetal structural defects and recent advances in various of prenatal diagnostics methods, some fetal structural defects may be diagnosed prenatallybefore birth.With the rapid development of "maternal-fetal medicine", some fetal structural defects are managed early through fetal surgery for achieving better infants’ prognosis and quality- of- life.Currently, maternal-fetal medicine and fetal surgical intervention have remained in their infancy in mainland China.There are differences exist in the understanding, diagnosis and treatment of fetal structural defects.This review paper focuseds up the epidemiology of fetal structural defects, the development of maternal-fetal medicine, and fetal surgery to offer a references for clinical practices.

参考文献/References:

[1] Corsello G, Giuffrè M.Congenital malformations[J].The Journal of Maternal-Fetal & Neonatal Medicine, 2012, 25(Suppl):25-29.DOI:10.3109/14767058.2012.664943.
[2] Chung SH, Kim CY, Lee BS.Congenital anomalies in very-low-birth-weight infants:a nationwide cohort study[J].Neonatology, 2020, 117(5):584-591.DOI:10.1159/000509117.
[3] Pitt MJ, Morris JK.European trends in mortality in children with congenital anomalies:2000-2015[J].Birth Defects Res, 2021, 113(12):958-967.DOI:10.1002/bdr2.1892.
[4] Mai CT, Isenburg JL, Canfield MA, et al.National population-based estimates for major birth defects, 2010-2014[J].Birth Defects Res, 2019, 111(18):1420-1435.DOI:10.1002/bdr2.1589.
[5] 中华人民共和国卫生部.中国出生缺陷防治报告2012[EB/OL].(2012).http://www.gov.cn/gzdt/att/att/site1/20120912/1c6f6506c7f811bacf9301.pdf. Ministry of Health of People’s Republic China:China Birth Defect Prevention Report[EB/OL].(2012).http://www.gov.cn/gzdt/att/att/site1/20120912/1c6f6506c7f811bacf9301.pdf.
[6] Postoev VA, Nieboer E, Grjibovski AM, et al.Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011:a register-based study[J].Reprod Health, 2015, 12:3.DOI:10.1186/1742-4755-12-3.
[7] Hod M, Lieberman N.Maternal-fetal medicine-how can we practically connect the "M" to the "F"?[J].Best Pract Res Clin Obstet Gynaecol, 2015, 29(2):270-283.DOI:10.1016/j.bpobgyn.2014.06.008.
[8] Lee King PA, Henderson ZT, Borders A.Advances in maternal fetal medicine:perinatal quality collaboratives working together to improve maternal outcomes[J].Clin Perinatol, 2020, 47(4):779-797.DOI:10.1016/j.clp.2020.08.009.
[9] Harrison MR, Golbus MS, Filly RA, et al.Management of the fetus with congenital hydronephrosis[J].J Pediatr Surg, 1982, 17(6):728-742.DOI:10.1016/s0022-3468(82)80437-5.
[10] Jancelewicz T, Harrison MR.A history of fetal surgery[J].Clin Perinatol, 2009, 36(2):227-236. DOI:10.1016/j.clp.2009.03.007.
[11] Watanabe M, Flake AW.Fetal surgery:progress and perspectives[J].Adv Pediatr, 2010, 57(1):353-372.DOI:10.1016/j.yapd.2010.08.011.
[12] Partridge EA, Flake AW.Maternal-fetal surgery for structural malformations[J].Best Pract Res Clin Obstet Gynaecol, 2012, 26(5):669-682.DOI:10.1016/j.bpobgyn.2012.03.003.
[13] Chandrasekharan PK, Rawat M, Madappa R, et al.Congenital Diaphragmatic hernia-a review[J].Matern Health Neonatol Perinatol, 2017, 3:6.DOI:10.1186/s40748-017-0045-1.
[14] 王伟鹏, 潘伟华, 王俊.先天性膈疝患儿围产期预后风险评估的研究进展[J].临床小儿外科杂志, 2019, 18(11):977-983.DOI:10.3969/j.issn.1671-6353.2019.11.016. Wang WP, Pan WH, Wang J.Assessing perinatal prognostic risks for children with congenital diaphragmatic hernia[J].J Clin Ped Sur, 2019, 18(11):977-983.DOI:10.3969/j.issn.1671-6353.2019.11.016.
[15] 马立霜, 孟楚怡.新生儿先天性膈疝诊治析评[J].临床小儿外科杂志, 2021, 20(9):801-807.DOI:10.12260/lcxewkzz.2021.09.001. Ma LS, Meng CY.Progress in diagnosis and treatment of neonatal congenital diaphragmatic hernia[J].J Clin Ped Sur, 2021, 20(9):801-807.DOI:10.12260/lcxewkzz.2021.09.001.
[16] Deprest J, Gratacos E, Nicolaides KH.Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia:evolution of a technique and preliminary results[J].Ultrasound Obstet Gynecol, 2004, 24(2):121-126.DOI:10.1002/uog.1711.
[17] Ruano R, Yoshisaki CT, da Silva MM, et al.A randomized controlled trial of fetal endoscopic tracheal occlusion versus postnatal management of severe isolated congenital diaphragmatic hernia[J].Ultrasound Obstet Gynecol, 2012, 39(1):20-27.DOI:10.1002/uog.10142.
[18] Jani JC, Nicolaides KH, Gratacós E, et al.Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion[J].Ultrasound Obstet Gynecol, 2009, 34(3):304-310.DOI:10.1002/uog.6450.
[19] Ruano R, Peiro JL, da Silva MM, et al.Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia:preliminary results[J].Ultrasound Obstet Gynecol, 2013, 42(1):70-76.DOI:10.1002/uog.12414.
[20] Ruano R, da Silva MM, Campos JA, et al.Fetal pulmonary response after fetoscopic tracheal occlusion for severe isolated congenital diaphragmatic hernia[J].Obstet Gynecol, 2012, 119(1):93-101.DOI:10.1097/AOG.0b013e31823d3aea.
[21] Jani JC, Nicolaides KH, Gratacós E, et al.Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion[J].Ultrasound Obstet Gynecol, 2009, 34(3):304-310.DOI:10.1002/uog.6450.
[22] Deprest JA, Nicolaides KH, Benachi A, et al.Randomized trial of fetal surgery for severe left diaphragmatic hernia[J].N Engl J Med, 2021, 385(2):107-118.DOI:10.1056/NEJMoa2027030.
[23] Deprest JA, Benachi A, Gratacos E, et al.Randomized trial of fetal surgery for moderate left diaphragmatic hernia[J].N Engl J Med, 2021, 385(2):119-129.DOI:10.1056/NEJMoa2026983.
[24] Seravalli V, Jelin EB, Miller JL, et al.Fetoscopic tracheal occlusion for treatment of non-isolated congenital diaphragmatic hernia[J].Prenat Diagn, 2017, 37(10):1046-1049.DOI:10.1002/pd.5139.
[25] Basurto D, Sananès N, Bleeser T, et al.Safety and efficacy of smart tracheal occlusion device in diaphragmatic hernia lamb model[J].Ultrasound Obstet Gynecol, 2021, 57(1):105-112.DOI:10.1002/uog.23135.
[26] Campiglio CE, Villonio M, Dellacà RL, et al.An injectable, degradable hydrogel plug for tracheal occlusion in congenital diaphragmatic hernia (CDH)[J].Mater Sci Eng C Mater Biol Appl, 2019, 99:430-439.DOI:10.1016/j.msec.2019.01.047.
[27] Perrone EE, Deprest JA.Fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia:a narrative review of the history, current practice, and future directions[J].Transl Pediatr, 2021, 10(5):1448-1460.DOI:10.21037/tp-20-130.
[28] Style CC, Olutoye OO, Belfort MA, et al.Fetal endoscopic tracheal occlusion reduces pulmonary hypertension in severe congenital diaphragmatic hernia[J].Ultrasound Obstet Gynecol, 2019, 54(6):752-758.DOI:10.1002/uog.20216.

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备注/Memo

收稿日期:2022-08-12。
通讯作者:施诚仁,Email:shicr629@163.com

更新日期/Last Update: 1900-01-01