Yue Yuhang,Li Lianyong.Risk factors and mechanisms of lower limb overgrowth after long bone diaphyseal fracture in children[J].Journal of Clinical Pediatric Surgery,2021,20(02):181-186.[doi:10.12260/lcxewkzz.2021.02.014]
儿童下肢长骨干骨折后过度生长的影响因素及机制研究进展
- Title:
- Risk factors and mechanisms of lower limb overgrowth after long bone diaphyseal fracture in children
- Keywords:
- Lover Extremity/IN; Fractures; Bone/CO; Bones/GD; Child
- 分类号:
- R726.8 R683.42
- 摘要:
- 下肢长骨干骨折是儿童常见创伤,主要包括股骨干骨折和胫骨干骨折。下肢长骨干骨折后通常会出现患肢的过度生长,导致双下肢不等长,并可继发背痛、脊柱侧弯和坐骨神经痛等症状。有研究发现,过度生长主要与骨折后骨膜完整性被破坏有关。骨折后骨膜在生长板两侧产生的压力降低,从而刺激骨骼生长。骨折后相关基因过表达,促进软骨细胞增殖分化,也可加速骨骼生长。本文旨在回顾下肢长骨干骨折后过度生长的相关临床及基础研究,并对可能存在的与过度生长有关的机制进行讨论。
- Abstract:
- Lower limb long bone fractures of femoral and tibial shafts are common in children.Frequent overgrowth at injured side may cause leg length inequality,low back pain,scoliosis and sciatica.The mechanism of overgrowth is probably related with the disruption of periosteum after fracture.The post-fracture periosteum reduces the pressure on growth plate and stimulates bone growth.Overexpression of related genes after fracture promotes proliferation and differentiation of chondrocytes and accelerates bone growth.This review summarized clinical and basic researches on the overgrowth of lower limbs after long bone diaphyseal fractures in children and elaborated upon the possible mechanisms of overgrowth.
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备注/Memo
收稿日期:2020-07-14。
通讯作者:李连永,Email:loyo_ldy@163.com