Zheng Dayou,Li Yanfang,Li Chuangye,et al.Comparison of metabolic differences between children with calcium oxalate stone and non-urolithiasis[J].Journal of Clinical Pediatric Surgery,2021,20(01):44-48.[doi:10.12260/lcxewkzz.2021.01.009]
草酸钙结石儿童与非结石儿童代谢差异的病例对照研究
- Title:
- Comparison of metabolic differences between children with calcium oxalate stone and non-urolithiasis
- Keywords:
- Calcium Oxalate; Metabolism; Calculi; Clild
- 分类号:
- R726.8;R691.4
- 摘要:
- 目的 比较草酸钙结石儿童（病例组）与非结石儿童（对照组）的血液及24小时尿液相关代谢指标差异。方法 选取2016年8月至2018年10月在湖南省儿童医院泌尿外科住院治疗并经结石成分分析主要成分为草酸钙的患者75例作为病例组，选取在本院住院治疗的75例非结石儿童（与病例组同年龄，同性别）作为对照组。测定血液及24小时尿液生化结果，比较病例组与对照组的血液及24小时尿液相关代谢指标差异。结果 两组单位体重尿量、单位体表面积草酸、单位体重总钙差异无统计学意义（P>0.05）；病例组单位体表面积枸橼酸[310.5（228.4，445.6）mg/1.73 m2]及尿枸橼酸浓度[135.9（103.9，178.6）mg/L]均低于对照组[446.9（251.5，600.4）mg/1.73 m2，153.3（114.7，257.7）mg/L]，差异有统计学意义（P<0.05）。病例组24小时尿液中草酸浓度高于对照组，差异有统计学意义（Z=-3.024，P<0.05）。两组血钾、钙、氯、尿素氮、肌酐、尿酸浓度差异无统计学意义（P>0.05）。病例组[（139.3±2.6）mmol/L]血钠高于对照组[（138.2±1.9）mmol/L]，差异有统计学意义（t=2.851，P<0.05）。结论 24小时尿液中草酸浓度、枸橼酸浓度及血钠浓度可能与儿童草酸钙结石形成有关，但儿童血钠及24小时尿液中相关代谢产物浓度是否可作为儿童草酸钙结石形成的危险因素，仍有待进一步探讨。
- Abstract:
- Objective To compare the indices of blood and 24-hour urine-related metabolites between children with calcium oxalate stone and non-urolithiasis.Methods From August 2016 to October 2018 at Hunan Children’s Hospital,this case-control study selected 75 children with calcium oxalate as case group and 75 non-urolithiasis counterparts of the same age/gender as control group.Blood and 24 hours urine biochemical results were measured and the differences of blood and 24 hours urine-related metabolic indices were compared between case and control groups.Results The excretions of 24 hours urine-related metabolites were compared:No significant inter-group difference existed in unit body weight urine volume,unit body surface area oxalic acid[310.5(228.4,445.6) mg/1.73 m2] or unit bodyweight total calcium[135.9(103.9,178.6) mg/L] [446.9(251.5,600.4) mg/1.73 m2,153.3(114.7,257.7) mg/L](Z=-2.795,Z=-2.020;P>0.05);the concentrations of unit body surface area citric acid and urinary citric acid in case group were lower than those in control group while the concentration of urinary oxalic acid was higher in case group than that in control group (Z=-3.024,P>0.05).No significant inter-group differences existed in blood concentrations of potassium,calcium,chlorine,urea nitrogen,creatinine or uric acid (P>0.05).Blood sodium in case group[139.3±2.6 mmol/L] was higher than that inontrol group[138.2±1.9 mmol/L] and the difference was statistically significant (t=2.851,P<0.05).Conclusion Urinary oxalic acid,urinary citrate and blood sodium concentrations may be correlated with the formation of calcium oxalate stone in children.However,further studies are required for elucidating the relationship between metabolite concentration and calcium oxalate stone.
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备注/Memo
收稿日期:2020-05-15。
基金项目:湖南省自然科学基金（编号：2017JJ2139）
通讯作者:赵夭望,Email:yw508@sina.com