Zhao Weihua,Zhu Guanghui.Application advances of tissue engineering and repair and reconstruction technology in pediatric surgery[J].Journal of Clinical Pediatric Surgery,2020,19(11):961-966.[doi:10.3969/j.issn.1671-6353.2020.11.001]
组织工程与修复重建技术在小儿外科的应用进展
- Title:
- Application advances of tissue engineering and repair and reconstruction technology in pediatric surgery
- 分类号:
- R726;R321-3
- 摘要:
- 儿童创伤、畸形、肿瘤、炎症等疾病可导致组织缺损，给组织工程与修复重建外科带来新的挑战。在过去30年里，组织工程与修复重建技术在小儿外科领域得到了长足发展。组织工程在皮肤、骨与软骨、肌腱、血管、肝脏、肾脏、膀胱、神经等领域应用广泛，相关器官的修复重建领域也有新的研究进展。各种新技术在种子细胞、生物材料和组织构建中的应用是组织工程与修复重建发展的基础，但应用到儿童群体，需要考虑其特殊性，如持续生长发育、免疫器官的逐步成熟、重建组织的再血管化及如何达到功能重建等。此外，有关组织工程与修复重建的伦理学问题也亟需解决。本文将介绍组织工程与修复重建技术在小儿外科领域的应用进展。
- Abstract:
- Trauma,deformity,tumor,inflammation and other diseases will lead to tissue defects in children.It brings new challenges to tissue engineering and reconstruction surgery.Over the last three decades,tissue engineering and reconstruction have made great advances in pediatric surgery.Tissue engineering has a wide range of clinical applications in skin,bone,cartilage,tendon,blood vessel,liver,kidney,bladder and nerve.Applications of various new technologies in seed cells,biomaterials and tissue construction is the developmental basis of tissue engineering and reconstruction surgery.However,clinicians should consider the particularity of children,such as continuous growth and development,gradual maturity of immune organs,revascularization of reconstructed tissues and how to achieve functional reconstruction.The ethical problems of tissue engineering and reconstruction also need to be resolved.This review summarized new advances,current challenges and coping strategies of tissue engineering and reconstruction technique in pediatric surgery.
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备注/Memo
收稿日期:2020-04-03。
基金项目:湖南省发展和改革委员会2019年创新研发项目（编号：湘发改投资[2019]875号）
通讯作者:赵卫华,Email:zhaoweihua100@163.com