[1]蒋鸿飞,林涛,石秦林.肾母细胞瘤综合治疗研究进展[J].临床小儿外科杂志,2020,19(10):916-920.[doi:10.3969/j.issn.1671-6353.2020.10.010]
　Jiang Hongfei,Lin Tao,Shi Qinlin.Research advances in the treatments of Wilms’ tumor[J].Journal of Clinical Pediatric Surgery,2020,19(10):916-920.[doi:10.3969/j.issn.1671-6353.2020.10.010]
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肾母细胞瘤综合治疗研究进展

《临床小儿外科杂志》[ISSN:1671-6353/CN:43-1380/R] 卷: 第19卷 期数: 2020年10期 页码: 916-920 栏目: 儿童肿瘤 出版日期: 2020-10-28
Title:
Research advances in the treatments of Wilms’ tumor
作者:
蒋鸿飞;  林涛;  石秦林
重庆医科大学附属儿童医院泌尿外科, 儿童泌尿生殖发育与组织工程重点实验室, 国家儿童健康与疾病临床医学研究中心, 儿童发育疾病研究教育部重点实验室, 儿童发育重大疾病国家国际科技合作基地, 儿科学重庆市重点实验室(重庆市, 400014)
Author(s):
Jiang Hongfei;  Lin Tao;  Shi Qinlin
Department of Pediatric Urology, Affiliated Children’s Hospital, Chongqing Medical University, Chongqing 400014, China
关键词:
Wilms瘤; 治疗; 研究
Keywords:
Wilms Tumor; Therapy; Research
分类号:
R737.11;R730.5
DOI:
10.3969/j.issn.1671-6353.2020.10.010
摘要:
肾母细胞瘤（nephroblastoma）是儿童常见的腹膜后肿瘤，发病率约0.8/100 000，大多数在1~3岁发病。多以腹部肿块而就诊，少部分因高血压、血尿、尿路感染、发热、厌食等原因被发现。少数患儿缺乏典型临床表现，常因肿瘤破裂和出血引起剧烈疼痛就诊。近30多年来，随着对肾母细胞瘤的深入研究及治疗水平提高，5年整体存活率由25%提高到90%，这主要归功于多学科综合治疗，但肾母细胞瘤的复发率依然高达15%。因此，早期发现肿瘤复发、转移，及时采取干预措施对其预后显得尤为重要。本文通过对肾母细胞瘤最新的治疗经验及研究做一综述，旨在优化个体化诊疗方案，加强随访，进一步提高患儿整体生存率。
Abstract:
Occurring mostly within 1-3 years of age,nephroblastoma is a common retroperitoneal tumor with an incidence of around 0.8/100,000.Most cases present with abdominal masses and few have hypertension,hematuria,urinary tract infection,fever and anorexia.Due to a lack of typical clinical symptoms,some cases develop severe pain due to tumor bleeding and rupture.Over the last three decades,with the in-depth mechanistic understandings and improved treatments,its 5-year overall survival has spiked from 25% to around 90% thanks to multidisciplinary interventions of chemotherapy,surgery and radiotherapy.However,its recurrent rate has hovered around 15%.Thus an early detection of tumor recurrence and metastasis is essential.This article offers a brief review of the latest treatments and researches of nephroblastoma.The objective is to optimize individual treatment protocols,strengthen their follow-ups and further improve their overall survival.

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备注/Memo

收稿日期:2019-02-10。
基金项目:重庆市渝中区科研项目（编号：20180155）
通讯作者:林涛,Email:lintao272@aliyun.com

更新日期/Last Update: 2020-10-28