Chen Zirong,Li Yakun,Wan Feng.Clinicopathological features of children with neurological tumors[J].Journal of Clinical Pediatric Surgery,2019,18(09):723-727.[doi:10.3969/j.issn.1671-6353.2019.09.003]
儿童神经肿瘤临床和病理特点
- Title:
- Clinicopathological features of children with neurological tumors
- 关键词:
- 神经系统肿瘤; 病理状态、体征和症状; 分子病理; 预后; 儿童
- Keywords:
- Nervous System Neoplasms; Pathological Conditions; Signs and Symptoms; Molecular Pathology; Prognosis; Child
- 分类号:
- R726;R739.4;R739.41
- 摘要:
- 神经肿瘤是儿童最常见的实体肿瘤，也是继血液系统恶性肿瘤外最常见的儿童肿瘤。在0~14岁患儿中，神经肿瘤的致死率显著高于其他类型肿瘤。从好发部位、病理类型以及基因改变等方面来看，儿童神经肿瘤与成人患者存在较大差异。同种病理类型的脑肿瘤，在儿童群体中可呈现出不同的生长方式和影像特点。儿童（特别是婴幼儿）恶性脑肿瘤的恶性程度往往较高，多数患儿无法接受放疗或对放疗不敏感，而化疗药物的选择和治疗效果也非常有限，因此预后通常较差。常见的低级别胶质瘤、颅咽管瘤具有缓慢进展或复发、病情容易迁延等一系列特点，提高患儿的生存质量离不开神经外科与其他学科的交叉合作。
- Abstract:
- Central nervous system (CNS) tumors are the most common pediatric cancers after hematological malignancies and the most common pediatric solid organ tumor.CNS tumors remain the most common cause of cancer-related mortality in children aged 0-14 years.Susceptible locations,pathologies and genetic aberrations of pediatric CNS tumors are significantly divergent from their adult counterparts.Meanwhile,they also manifest vastly different growth and imaging characteristics.Radiochemotherapy is often associated with poor outcomes.For infants and young children with highly malignant tumors,radiotherapy is not applicable.Meanwhile,the most common low-grade gliomas and other benign tumors such as craniopharyngioma,have slow progression and recurrence.Improving the quality-of-life and prognosis of pediatric CNS tumors requires more extensive multidisciplinary collaborations.
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备注/Memo
收稿日期:2019-05-13。
通讯作者:万锋,Email:wanruiyan@hotmail.com