Xia Hongliang,Wang Jian.Research advances in molecular biological mechanisms of testicular ischemia-reperfusion injury[J].Journal of Clinical Pediatric Surgery,2019,18(07):611-614,618.[doi:10.3969/j.issn.1671-6353.2019.07.018]
睾丸缺血再灌注损伤分子生物学机制研究进展
- Title:
- Research advances in molecular biological mechanisms of testicular ischemia-reperfusion injury
- Keywords:
- Testis; Melocular Biology; Reperfution Injury
- 分类号:
- R726.9;R393
- 摘要:
- 睾丸扭转是男性新生儿及青少年常见的泌尿生殖系统急症，扭转后如果不及时进行处理可导致睾丸组织缺血坏死。同时，睾丸扭转复位后缺血再灌注损伤也是导致睾丸生精功能障碍和激素分泌功能障碍的重要原因。但在睾丸缺血再灌注损伤的病理生理过程中，细胞和分子参与其发生、发展过程的具体机制尚未完全明确，因此笔者将针对睾丸缺血再灌注损伤的分子生物学机制研究进展作一综述。
- Abstract:
- Testicular torsion is a common urogenital emergency in male neonates and adolescents.If not treated timely,it can lead to ischemic necrosis of testicular tissue.Also ischemia-reperfusion injury after testicular torsion reduction is an important cause of testicular spermatogenic and hormone-secreting dysfunctions.However,during the pathophysiological process of testicular ischemia-reperfusion injury,the specific mechanisms of cells and molecules involved in its occurrence and development have not been fully clarified.Here the authors review researches of molecular biological mechanism of testicular ischemia-reperfusion injury.
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备注/Memo
收稿日期:2017-9-27。
基金项目:江苏省卫生与计划生育委员会面上项目（编号：H2017067）
通讯作者:夏红亮,Email:liangrous@hotmail.com