Qu Zhibo,Zhang Haoran.Advances in autophagy regulation and neuroblastoma[J].Journal of Clinical Pediatric Surgery,2019,18(03):242-246,249.[doi:10.3969/j.issn.1671-6353.2019.03.017]
自噬调控在神经母细胞瘤中的作用研究进展
- Title:
- Advances in autophagy regulation and neuroblastoma
- Keywords:
- Autophagy; Neuroblastoma
- 分类号:
- R729;R739.4
- 摘要:
- 神经母细胞瘤是儿童和婴儿时期常见的实体肿瘤之一，早期即可发生转移，恶性度极高。本病的治疗以手术联合化疗为主，但预后不理想。因此寻找新的治疗靶点是当今的研究热点之一。近年来研究发现，细胞自噬调控异常与肿瘤的炎症反应、能量代谢、细胞程序性死亡及对肿瘤治疗的耐药性等方面有密切联系。因此，本文就细胞自噬调控与神经母细胞瘤之间的关系作一综述，旨在为神经母细胞瘤防治工作提供新的思路。
- Abstract:
- Neuroblastoma is one of the most common solid tumors in children and infants.The treatment of this disease is mainly surgery combined with chemotherapy,but the prognosis is not ideal.Therefore, the search for new therapeutic targets is one of the hot spots in current research.Recent studies have shown that abnormal regulation of autophagy is closely related to inflammatory response,energy metabolism,programmed cell death and resistance to tumor therapy.This paper summarizes the relationship between autophagy regulation and neuroblastoma,aiming to provide new ideas for the prevention and treatment of neuroblastoma.
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备注/Memo
收稿日期:2018-01-15。
基金项目:哈尔滨市科技局科技创新人才研究专项基金后备人才项目资助（编号：2014RFQGJ124）
通讯作者:曲志博,Email:zhiboqu@126.com