YIN Min-zhi,CHEN Qi-min,ZHANG Zhong-de,et al.he analysis of paediatric inflammatory myofibroblastic tumor’s clinicopathological features,lectures review[J].Journal of Clinical Pediatric Surgery,2013,12(02):97-99.[doi:10.3969/j.issn.1671— 6353.2013.02.006]
儿童胸部炎性肌纤维母细胞瘤的临床病理探讨
- Title:
- he analysis of paediatric inflammatory myofibroblastic tumor’s clinicopathological features,lectures review
- Keywords:
- Neoplasms; Muscle Tissue/PA; Myositis; Child
- 摘要:
- 目的 探讨4例儿童胸部炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)的临床病理特点、诊断与治疗。 方法 对4例儿童胸部IMT患儿的临床资料、病理组织学包括免疫组织化学检查,结合文献进行分析。 结果 4例中,男3例,女1例,年龄14个月至4岁。病变部位分别为胸腔及上呼吸道。临床以反复呼吸道感染、长期咳嗽为主,2例首诊为支气管肺炎,2例首诊为胸腔占位性病变继发感染。实验室检查无特殊; CT检查提示:2例左下肺炎性实变,2例胸部圆形实体肿物。镜下见肿瘤由肌纤维母细胞性梭形细胞伴炎症细胞构成。免疫组化结果:4例vimentin、ALK1弥漫阳性、Desmin、SMA局灶阳性; 2例MSA局灶阳性; S-100均为阴性。 结论 儿童胸部IMT是罕见的中间型梭形细胞肿瘤,临床表现无特异性; 确诊依靠病理学检查和免疫组化; 手术切除是有效的治疗方法,但存在复发与转移,术后需长期随访。
- Abstract:
- Objetive To explore the clinicopathological features of inflammatory myofibroblastic tumor(IMT)and investigate the diagnosis and treatment. Methods 4 cases of children’s IMT were analyzed with HE stain and immunohistochemical technique, the literatures were reviewed. Results one was a girl and the other 3 were boys, the mean age were 3 years-old, laboratory findings no significant, histological showed the tumor was composed of(myo)/ fibrobastic spindle cells with inflammatory cells. Immunohistochemical examination of the tumors were as follows: vimentin、ALK1, and variably were positive,and Desmin、SMA、MSA were sported, positive, S100 was negative. Conclusions IMTs is a rare spindle cells in an inflammatory background.The clinical characteristics is no significant, histological examination combined with immunohistochemical study can discover the exactly diagnosis. Surgery is the main treatment modility. And because of its local invasiveness and its tendency to recur, a careful follow-up is required.
参考文献/References:
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