目的 探讨低体重早产儿动脉导管未闭(PDA)的早期手术干预方法及疗效。 方法 2012年1月至2015年12月本院收治33例低体重早产儿PDA,均在NICU协助下进行手术治疗。根据治疗方案分为药物治疗失败后采用Prolene缝线结扎未闭动脉导管组(G1组)和直接采用Prolene缝线结扎未闭动脉导管组(G2组)两组,比较两组病史、临床资料、病死率及主要并发症情况。 结果 两组病史因素及临床资料比较,差异无统计学意义(P>0.05)。G2组无一例死亡,G1组病死率为1 3%,差异有统计学意义(χ2= 28,P<0.05),G2组并发症的发生率为1 1%,G1组并发症的发生率为3 3%,差异有统计学意义(χ2=1 92,P<0.05)。 结论 早期在NICU与外科协作下选用Prolene缝线结扎未闭动脉导管是PDA安全有效的治疗方式。
Objective To explore the surgical efficacies of patent ductus arteriosus(PDA)in neonatal intensive care unit(NICU)in low birth weight premature infants. Methods Thirty-three low-birth-weight preterm PDA infants operated in NICU between January 2012 and December 2015 were selected and divided into two groups. The inter-group differences in medical history,clinical status,mortality and major complications were analyzed. Results No statistical significance existed in medical history or clinical profiles between two groups(P>0.05).The mortality was 0% in group G2 versus 1 3% in group G The difference was statistically significant(χ2= 28,P<0.05).And the complication rate was 3 3% in group G1 versus 1 1% in group G2(P<0.05).The difference was statistically significant(χ2=1 92,P<0.05). Conclusion NICU collaboration with surgery and Prolene suture are safe and efficacious for premature infants with patent ductus arteriosus.