临床小儿外科杂志

目的利用Meta分析探讨母亲及子代甲硫氨酸合酶还原酶(MTRR)基因A66G多态性与神经管缺陷(NTDs)发生的相关性。方法检索万方数据库、中国知网、中国生物医学文献数据库、中文科技期刊数据库、PubMed和Web of Science等中英文数据库,检索时间均为自建库至2015年11月。按照纳入标准选取有关母亲和(或)子代MTRR基因A66G多态性与NTDs发生相关的病例对照研究的学术期刊文献及其

Objective To evaluate the associations between gene polymorphism of maternal and offsprings'methionine synthase reductase(MTRR)A66G and neural tube defects(NTDs). Methods Based on inclusion criteria and retrieval strategy,the relevant literatures were identified by searches for case-control studies on the correlations between gene polymorphism of maternal and(or)offsprings' MTRR A66G with NTDs in the following databases of Wangfang,China National Knowledge Infrastructure(CNKI),China Biology Medical Literature Database(CBM),Database of Chinese Scientific and Technical Periodicals(VIP),PubMed and Web of Science from initial setup to November 201 And the data were quantitatively analyzed by Rev Man 0 and STATA 1 0 software. Results Among 16 eligible studies,11 studies(1 284 cases and 2 182 controls)were on maternal MTRR A66G polymorphism and 11 studies(1 567 cases and 2 621 controls)about offsprings'MTRR A66G polymorphism. Combined OR(95%CI)on maternal MTRR A66G co-dominant model(GG vs AA)and allele(G vs A)were 55( 06～ 27)and 22( 01～ 47)respectively and those on offsprings' co-dominant model(AG vs AA)were 47( 05～ 05). The results were significantly different. Conclusion Both maternal and offsprings' MTRR gene A66G polymorphism are risk factors of NTDs.

引言
1 材料与方法
2 结果
3 讨论

图1 文献筛选流程及结果<br/>Fig.1 Flows and outcomes of screening related articles

图1 文献筛选流程及结果
Fig.1 Flows and outcomes of screening related articles

表1 纳入文献特征<br/>Table 1 Characteristics of studies included for meta-analysis

表1 纳入文献特征
Table 1 Characteristics of studies included for meta-analysis

图2 母亲MTRR A66G基因多态性与子代NTDs关系的共显性模型的森林图(GG vs AA)<br/>Fig.2 Forest plot for correlation between maternal MTRR A66G polymorphism and NTDs from co-dominant model(GG vs AA)

图2 母亲MTRR A66G基因多态性与子代NTDs关系的共显性模型的森林图(GG vs AA)
Fig.2 Forest plot for correlation between maternal MTRR A66G polymorphism and NTDs from co-dominant model(GG vs AA)

图3 母亲MTRR A66G基因多态性与子代NTDs关系的共显性模型的森林图(AG vs AA)<br/>Fig.3 Forest plot for correlation of maternal MTRR A66G polymorphism and NTDs from co-dominant model(AG vs AA)

图3 母亲MTRR A66G基因多态性与子代NTDs关系的共显性模型的森林图(AG vs AA)
Fig.3 Forest plot for correlation of maternal MTRR A66G polymorphism and NTDs from co-dominant model(AG vs AA)

图4 母亲MTRR A66G基因多态性与子代NTDs关系的等位基因的森林图(G vs A)<br/>Fig.4 Forest plot for correlation between maternal MTRR A66G polymorphism and NTDs from allele(G vs A)

图4 母亲MTRR A66G基因多态性与子代NTDs关系的等位基因的森林图(G vs A)
Fig.4 Forest plot for correlation between maternal MTRR A66G polymorphism and NTDs from allele(G vs A)

图5 剔除不符合HWE文献后子代MTRR A66G基因多态性与NTDs关系的共显性模型的森林图(GG vs AA)<br/>Fig.5 Forest plot for correlation between offsprings' MTRR A66G polymorphism and NTDs from co-dominant model(GG vs AA) after excluding non-HWE studies

图5 剔除不符合HWE文献后子代MTRR A66G基因多态性与NTDs关系的共显性模型的森林图(GG vs AA)
Fig.5 Forest plot for correlation between offsprings' MTRR A66G polymorphism and NTDs from co-dominant model(GG vs AA) after excluding non-HWE studies

图6 子代MTRR A66G基因多态性共显性模型的森林图(AG vs AA)<br/>Fig.6 Forest plot for correlation between offsprings' MTRR A66G polymorphism and NTDs from co-dominant model(AG vs AA)

图6 子代MTRR A66G基因多态性共显性模型的森林图(AG vs AA)
Fig.6 Forest plot for correlation between offsprings' MTRR A66G polymorphism and NTDs from co-dominant model(AG vs AA)

图7 剔除不符合HWE文献后的子代MTRR A66G基因多态性与NTDs关系的等位基因的森林图(G vs A)<br/>Fig.7 Forest plot for correlation between offsprings' MTRR A66G polymorphism and NTDs from allele(G vs A)after excluding studies not in HWE

图7 剔除不符合HWE文献后的子代MTRR A66G基因多态性与NTDs关系的等位基因的森林图(G vs A)
Fig.7 Forest plot for correlation between offsprings' MTRR A66G polymorphism and NTDs from allele(G vs A)after excluding studies not in HWE

图8 母亲基因型AG发表偏倚漏斗图<br/>Fig.8 Funnel plot of maternal AG genotype publication bias

图8 母亲基因型AG发表偏倚漏斗图
Fig.8 Funnel plot of maternal AG genotype publication bias

图9 子代基因型AG发表偏倚漏斗图<br/>Fig.9 Funnel plot of offsprings' AG genotype publication bias

图9 子代基因型AG发表偏倚漏斗图
Fig.9 Funnel plot of offsprings' AG genotype publication bias

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备注

引言

1 材料与方法

2 结果

3 讨论

期刊信息

备注

引言

1 材料与方法

2 结 果

3 讨 论

期刊信息

2 结果

3 讨论