甲硫氨酸合酶还原酶基因A66G多态性与神经管缺陷关系的Meta分析
张瑞苹1,方玉莲2,Nirja Lakhey1,Mohamed Nasar Chemban1,吴 波1,蔡春泉3

天津医科大学研究生院(天津市,300070); 天津市儿童医院儿科研究所(天津市,300074); 天津市儿童医院神经外科(天津市,300074)

神经管缺损; 甲硫氨酸合酶还原酶(MTRR); 基因多态性; Meta分析

Association of gene polymorphism of methionine synthase reductase A66G with neural tube defectsa:ameta-analysis.
Zhang Ruiping1, Fang Yulian2, Nirja Lakhey1, Mohamed Nasar, Chemban1, Wu Bo1, Cai Chunquan3

Graduate School,Tianjin Medical University,Tianjin 300070,China; Institute of Pediatrics,Tianjin Children's Hospital,Tianjin 300074,China; Department of Neurosurgery,Tianjin Children's Hospital,Tianjin 300074,China.Corresponding author: Cai Chunquan,Email: tjpns@12 com

Neural Tube Defects; Methionine Synthase Reductase; Gene Polymorphism; Meta-Analysis

DOI: 10.3969/j.issn.1671— 635 201 0 009

备注

目的 利用Meta分析探讨母亲及子代甲硫氨酸合酶还原酶(MTRR)基因A66G多态性与神经管缺陷(NTDs)发生的相关性。 方法 检索万方数据库、中国知网、中国生物医学文献数据库、中文科技期刊数据库、PubMed和Web of Science等中英文数据库,检索时间均为自建库至2015年11月。按照纳入标准选取有关母亲和(或)子代MTRR基因A66G多态性与NTDs发生相关的病例对照研究的学术期刊文献及其
Objective To evaluate the associations between gene polymorphism of maternal and offsprings'methionine synthase reductase(MTRR)A66G and neural tube defects(NTDs). Methods Based on inclusion criteria and retrieval strategy,the relevant literatures were identified by searches for case-control studies on the correlations between gene polymorphism of maternal and(or)offsprings' MTRR A66G with NTDs in the following databases of Wangfang,China National Knowledge Infrastructure(CNKI),China Biology Medical Literature Database(CBM),Database of Chinese Scientific and Technical Periodicals(VIP),PubMed and Web of Science from initial setup to November 201 And the data were quantitatively analyzed by Rev Man 0 and STATA 1 0 software. Results Among 16 eligible studies,11 studies(1 284 cases and 2 182 controls)were on maternal MTRR A66G polymorphism and 11 studies(1 567 cases and 2 621 controls)about offsprings'MTRR A66G polymorphism. Combined OR(95%CI)on maternal MTRR A66G co-dominant model(GG vs AA)and allele(G vs A)were 55( 06~ 27)and 22( 01~ 47)respectively and those on offsprings' co-dominant model(AG vs AA)were 47( 05~ 05). The results were significantly different. Conclusion Both maternal and offsprings' MTRR gene A66G polymorphism are risk factors of NTDs.