计算机辅助手术系统对各年龄段小儿肝脏体积的大数据分析及临床意义

青岛大学附属医院小儿外科,山东省数字医学与计算机辅助手术重点实验室(山东省青岛市,266003)

肝脏体积; 大数据分析; 数字医学; 肝脏体积模型

Aging and liver volume,big data analysis based on Hisense computer assisted surgery system and its clinical application.
Geng Geng, Cui kaiyue, Zhu Chengzhan, Zhou Xianjun, Dong Qian, Zhang Hong, Xing Maoqing, Lu Hongting, Jiang Zhong, Hao Xiwei, Wei Bin, Zhao Jing, Zhang Huanyu.

Department of Pediatric Surgery,Affiliated Hospital,Qingdao University,Shandong Key Laboratory of Digital Medicine & Computer-Assisted Surgery,Qingdao 266003,China.Corresponding author:Dong Qian,E-mail: 18661801885@16 com

Liver Volume; Big Data; Digital Medicine; Liver Volume Model

DOI: 10.3969/j.issn.1671— 635 201 0 007

备注

目的 应用海信CAS计算机辅助手术系统获取儿童各年龄段肝脏体积并进行大数据分析,建立中国儿童肝脏体积范围标准,为医疗和科研提供参考。 方法 应用海信CAS计算机辅助手术系统对696例国内儿童肝脏的CT影像资料进行三维重建,其中对增强CT进行肝脏及肝脏脉管系统、胆囊三维重建共457例(男201例,女256例),对平扫CT进行肝脏三维重建共239例(男129例,女110例)。按照年龄划分成19组,统计海信CAS计算机辅助手术系统测量的各年龄段研究对象肝脏体积及性别,最后进行统计学分析。 结果 同一年龄段(13~18岁年龄段除外)不同性别肝脏体积不存在差异(P>0.05)。各年龄段研究对象男女性别差异及年龄与体积线性相关关系如下:0~3岁:男女性别间无差异(P>0.05),年龄x(月)与肝脏体积y(cm3)的正相关关系极其明显,回归方程y= 344x+19 68(P<0.05,r=0.861 1)。3~6岁:男女性别间无差异(P>0.05),回归方程y= 228 3x+309(P<0.05,r=0.614 2)。6~12周岁:男女性别间无差异(P>0.05),回归方程y=7 252x+27 63(P<0.05,r=0.801 0)。12~18周岁:男女性别间存在差异(P<0.05),男性肝脏体积大于女性肝脏体积,回归方程y=40.571x+65 82(P<0.05,r=0.577 4)。 结论 小儿肝脏体积随年龄变化而变化,这一研究初步建立了中国小儿肝脏体积的范围标准,在小儿肝脏形态学、肝脏再生、肝脏功能、肝胆外科以及小儿肝脏移植等领域具有一定的参考价值。
Objective To measure liver volume using a previously validated system of computer-assisted liver volume measurement called Hisense CAS and perform big data analysis for establishing the Chinese children's standard liver volume model for medical and scientific researches. Methods Hisense CAS was used for measuring liver volumes from serial CT scans from 696 normal cases(thin-layer enhanced computed tomography(CT)scans 457 cases,including 201 boys and 256 girls; plain CT scans 239 cases,including 129 boys and 110 girls)and three-dimensionally reconstruct liver,gall bladder,blood vessels and liver alone respectively. In 19 groups,we collected and analyzed volume data with statistic software respectively to obtain the correlation coefficient and linear regression equation. Whether or not a relationship existed between liver volume and age and marked difference between boy and girl or not. Results 0~3 years:y= 344 x+19 68(P<0.05,r=0.861 1); 3~6 years:y = 228 3 x+309(P<0.05,r=0.614 2); 6~12 years:y=7 252 x+27 63(P<0.05,r=0.801 0); 12~18 years:y=40.571 x+65 82(P <0.05,r=0.577 4). Conclusion Human liver volume changes with age. Hisense CAS can precisely measure liver volume. And pediatric liver volume changes with age. Our study has established the scope of Chinese children ' s standard liver volume. It serves as useful guides for liver morphology,pediatric liver regeneration,pediatric liver function,pediatric hepatobiliary surgery,pediatric liver transplantation and other fields.