临床小儿外科杂志

目的应用海信CAS计算机辅助手术系统获取儿童各年龄段肝脏体积并进行大数据分析,建立中国儿童肝脏体积范围标准,为医疗和科研提供参考。方法应用海信CAS计算机辅助手术系统对696例国内儿童肝脏的CT影像资料进行三维重建,其中对增强CT进行肝脏及肝脏脉管系统、胆囊三维重建共457例(男201例,女256例),对平扫CT进行肝脏三维重建共239例(男129例,女110例)。按照年龄划分成19组,统计海信CAS计算机辅助手术系统测量的各年龄段研究对象肝脏体积及性别,最后进行统计学分析。结果同一年龄段(13～18岁年龄段除外)不同性别肝脏体积不存在差异(P>0.05)。各年龄段研究对象男女性别差异及年龄与体积线性相关关系如下:0～3岁:男女性别间无差异(P>0.05),年龄x(月)与肝脏体积y(cm3)的正相关关系极其明显,回归方程y= 344x+19 68(P<0.05,r=0.861 1)。3～6岁:男女性别间无差异(P>0.05),回归方程y= 228 3x+309(P<0.05,r=0.614 2)。6～12周岁:男女性别间无差异(P>0.05),回归方程y=7 252x+27 63(P<0.05,r=0.801 0)。12～18周岁:男女性别间存在差异(P<0.05),男性肝脏体积大于女性肝脏体积,回归方程y=40.571x+65 82(P<0.05,r=0.577 4)。结论小儿肝脏体积随年龄变化而变化,这一研究初步建立了中国小儿肝脏体积的范围标准,在小儿肝脏形态学、肝脏再生、肝脏功能、肝胆外科以及小儿肝脏移植等领域具有一定的参考价值。

Objective To measure liver volume using a previously validated system of computer-assisted liver volume measurement called Hisense CAS and perform big data analysis for establishing the Chinese children's standard liver volume model for medical and scientific researches. Methods Hisense CAS was used for measuring liver volumes from serial CT scans from 696 normal cases(thin-layer enhanced computed tomography(CT)scans 457 cases,including 201 boys and 256 girls; plain CT scans 239 cases,including 129 boys and 110 girls)and three-dimensionally reconstruct liver,gall bladder,blood vessels and liver alone respectively. In 19 groups,we collected and analyzed volume data with statistic software respectively to obtain the correlation coefficient and linear regression equation. Whether or not a relationship existed between liver volume and age and marked difference between boy and girl or not. Results 0～3 years:y= 344 x+19 68(P<0.05,r=0.861 1); 3～6 years:y = 228 3 x+309(P<0.05,r=0.614 2); 6～12 years:y=7 252 x+27 63(P<0.05,r=0.801 0); 12～18 years:y=40.571 x+65 82(P <0.05,r=0.577 4). Conclusion Human liver volume changes with age. Hisense CAS can precisely measure liver volume. And pediatric liver volume changes with age. Our study has established the scope of Chinese children ' s standard liver volume. It serves as useful guides for liver morphology,pediatric liver regeneration,pediatric liver function,pediatric hepatobiliary surgery,pediatric liver transplantation and other fields.

引言
1 材料与方法
2 结果
3 讨论

表1 696例儿童年龄和性别分布情况(n)<br/>Table 1 The distribution of age,gender among 696 children

表1 696例儿童年龄和性别分布情况(n)
Table 1 The distribution of age,gender among 696 children

表2 696例儿童不同年龄分组和各组肝脏体积<br/>Table 2 Standard liver volume range

表2 696例儿童不同年龄分组和各组肝脏体积
Table 2 Standard liver volume range

表3 696例儿童同一年龄段不同性别肝脏体积的比较(cm3)<br/>Table 3 Comparisons of liver volume between both genders in 696 children(cm3)

表3 696例儿童同一年龄段不同性别肝脏体积的比较(cm3)
Table 3 Comparisons of liver volume between both genders in 696 children(cm3)

图1 — 1 海信CAS计算机辅助手术系统对肝脏、胆囊、各脉管系统的三维重建; 图 1— 2 海信CAS计算机辅助手术系统对肝静脉系统的三维重建; 图 1— 3 海信CAS计算机辅助手术系统对门静脉系统的三维重建; 图 1— 4 海信CAS计算机辅助手术系统对肝脏的三维重建<br/>Fig.1 — 1 The 3D reconstruction of the liver,gall bladder and vessel system; Fig.1— 2 The 3D reconstruction of the hepatic vein branches; Fig.1— 3 The 3D reconstruction of the portal vein branches; Fig.1— 4 The 3D reconstruction of liver.

图1 — 1 海信CAS计算机辅助手术系统对肝脏、胆囊、各脉管系统的三维重建; 图 1— 2 海信CAS计算机辅助手术系统对肝静脉系统的三维重建; 图 1— 3 海信CAS计算机辅助手术系统对门静脉系统的三维重建; 图 1— 4 海信CAS计算机辅助手术系统对肝脏的三维重建
Fig.1 — 1 The 3D reconstruction of the liver,gall bladder and vessel system; Fig.1— 2 The 3D reconstruction of the hepatic vein branches; Fig.1— 3 The 3D reconstruction of the portal vein branches; Fig.1— 4 The 3D reconstruction of liver.

图2 — 10～36月龄小儿年龄与肝脏体积相关性散点图图 2-2 4～6月龄小儿年龄与肝脏体积相关性散点图图 2-3 7～12岁小儿年龄与肝脏总体积相关性散点图图 2-4 13～18 岁小儿年龄与肝脏总体积相关性散点图<br/>Fig.2 — 1 Scatterplot of the correlation of age and total liver volume in 0～36 months old children Fig.2-2 Scatterplot of the correlation of age and total liver volume in 36～72 months old children Fig.2-3 Scatterplot of the correlation of age and total liver volume in 7～12 years old children Fig.2-4 Scatterplot of the correlation of age and total liver volume in 13～18 years old children

图2 — 10～36月龄小儿年龄与肝脏体积相关性散点图图 2-2 4～6月龄小儿年龄与肝脏体积相关性散点图图 2-3 7～12岁小儿年龄与肝脏总体积相关性散点图图 2-4 13～18 岁小儿年龄与肝脏总体积相关性散点图
Fig.2 — 1 Scatterplot of the correlation of age and total liver volume in 0～36 months old children Fig.2-2 Scatterplot of the correlation of age and total liver volume in 36～72 months old children Fig.2-3 Scatterplot of the correlation of age and total liver volume in 7～12 years old children Fig.2-4 Scatterplot of the correlation of age and total liver volume in 13～18 years old children

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备注

引言

1 材料与方法

2 结果

3 讨论

期刊信息

备注

引言

1 材料与方法

2 结 果

3 讨 论

期刊信息

2 结果

3 讨论