Wang Changfeng,Sun Jiali,Wu Changhua,et al.Curative efficacy of timolol plus 595nm pulsed dye laser for superficial infantile hemangioma[J].Journal of Clinical Pediatric Surgery,2019,18(11):953-958.[doi:10.3969/j.issn.1671—6353.2019.11.011]
595 nm脉冲染料激光联合噻吗洛尔滴眼液治疗浅表性婴幼儿血管瘤的疗效观察
- Title:
- Curative efficacy of timolol plus 595nm pulsed dye laser for superficial infantile hemangioma
- Keywords:
- Hemangioma; Lasers; Timolol; Treatment Outcome; Infant
- 分类号:
- R543;R318.51
- 摘要:
- 目的 对比单独应用595 nm脉冲染料激光、单独应用0.5%噻吗洛尔滴眼液及两者联合应用3种不同方案治疗浅表性婴幼儿血管瘤的疗效。方法 以2018年6月至2019年6月于山东大学齐鲁儿童医院接受治疗的156例婴幼儿血管瘤患者为研究对象，按照治疗方案的不同分为激光治疗组（n=64）、外敷治疗组（n=60）、联合治疗组（n=32），3组患儿每月接受复查，通过拍照及超声检查记录瘤体变化情况；治疗后随访1个月，记录患儿性别、病变大小、病变部位、治疗次数、治愈率和不良反应。结果 联合治疗组的有效率（96.9%，31/32）与激光治疗组（95.3%，61/64）、外敷治疗组（95%，57/60）比较均不存在显著性差异（P>0.05）。与激光治疗组（29.7%，19/64）和外敷治疗组（18.3%，11/60）相比，联合治疗组（56.3%，18/32）中有更多患者疗效评级达到4级（P<0.05），且联合治疗组达到疗效评价4级所需的治疗时间为（3.3±0.21）个月，明显短于激光治疗组、外敷治疗组（P<0.05）；3组均无一例出现严重并发症。结论 595 nm脉冲染料激光与0.5%噻吗洛尔滴眼液联合应用治疗浅表性婴幼儿血管瘤安全、有效。
- Abstract:
- Objective To explore the curative efficacy of 595nm pulsed dye laser plus 0.5% timolol for superficial infantile hemangiomas.Methods From June 2018 to June 2019,a total of 156 hemangioma children were recruited and divided into three groups of pulsed dye laser (n=64),external timolol (n=60) and combination treatment (n=32).Three groups were reviewed monthly and tumor changes monitored by photograph and ultrasound.Four levels of efficacy evaluations were assigned and the data of gender,lesion size/location,treatment frequency,curative rate and adverse reactions recorded.The treatment outcomes of three groups were compared.Results The effective rate of combination treatment group (96.9%,31/32) was not statistically different from those of pulsed dye laser group (95.3%,61/64) and timolol group (95%,57/60).As compared with pulsed dye laser (29.7%,19/64) and timolol groups (18.3%,11/60),the efficacy of combination treatment (56.3%,18/32) was more inclined to level 4 (P<0.05).The time to reach grade 4 treatment in combination treatment group was (3.3±0.21) months and it was significantly lower than that in either treatment group alone (P<0.05).No serious complications occurred in three groups.Conclusion Curative efficacy of timolol plus 595nm pulsed dye laser is superior to that of simple application of timolol or 595nm pulsed dye laser alone.
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备注/Memo
收稿日期:2019-08-01。
基金项目:济南市卫生和计划生育委员会科技计划项目（编号：2016-1-16）
通讯作者:郭磊,Email:1045264128@qq.com