An Zongjian,Sun Yong.Research advances of neonatal intestinal microbiome and necrotising enterocolitis[J].Journal of Clinical Pediatric Surgery,2019,18(05):356-360.[doi:10.3969/j.issn.1671-6353.2019.05.004]
新生儿肠道菌群与坏死性小肠结肠炎发病关系的研究进展
- Title:
- Research advances of neonatal intestinal microbiome and necrotising enterocolitis
- Keywords:
- Enterocolitis; Necrotizing/SU; Infant; Newborn; Retrospective Studies
- 分类号:
- R722.1;R378.2;R574.62
- 摘要:
- 新生儿坏死性小肠结肠炎（necrotising enterocolitis，NEC）是常见的新生儿肠道炎症性疾病之一，病死率较高。近年来其发病率有逐渐上升的趋势，然而其致病机制并未完全阐明。随着对NEC研究的不断深入以及高通量测序技术的迅猛发展，越来越多的研究表明NEC的发生与肠道菌群的紊乱有密切关系。本文对近年来研究新生儿肠道菌群与坏死性小肠结肠炎发病关系的相关文献进行综述，为NEC的预防及治疗提供参考依据。
- Abstract:
- Necrotising enterocolitis (NEC) is a common and yet lethal intestinal inflammatory disease of neonates.In recent years,the incidence rate of NEC is rising.However,its underlying mechanism has remained elusive.Intensive researches have been conducted with emerging high-throughput sequencing technology.More and more studies have implicated a strong correlation between abnormal development of gut microbiota and its onset.This article reviewed recent researches of infantile gut microbiota and NEC to provide new perspectives for its prevention and treatment.
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备注/Memo
收稿日期:2018-07-24。
基金项目:青岛市医药科研指导计划项目（编号：2017-WJZD111）
通讯作者:孙勇,Email:shsunyong@163.com