Wang JUNQIN,Jin Wen.Relationship between changes of coagulation function,disease progression and prognosis after acute traumatic brain injury in children[J].Journal of Clinical Pediatric Surgery,,22():149-153.[doi:10.3760/cma.j.cn101785-202202018-010]
Relationship between changes of coagulation function,disease progression and prognosis after acute traumatic brain injury in children
- Keywords:
- Brain Injuries; Traumatic; Blood Coagulation; Prognosis; Correlation of Data; Child
- Abstract:
- Objective To explore the relationship between coagulation parameters,disease progression and short-term prognoses in children with acute traumatic brain injury.Methods From March 2020 to March 2021,clinical data were retrospectively reviewed for 389 children with acute traumatic brain injury.Coagulation parameters,severity of brain injury and Glasgow Outcome Scale (GOS) of all children were collected at admission.And the relationship between changes of coagulation parameters,severity of brain injury and GOS was analyzed by Logistic regression.Results Age,computed tomography (CT) manifestations and treatments methods among children with different degrees of traumatic brain injury were significantly different (P<0.05).The differences of prothrombin time (PT),international normalized ratio (INR),fibrinogen (FIB),thrombin time (APTT),D-dimer (D-D),platelet (PLT) and fibrin degradation product (FDP) in mild,moderate and severe traumatic brain injury were statistically significant (P<0.05).During a follow-up period of 6 months,a significant negative correlation existed between injury severity and GOS (r=0.666,P<0.05).The values of INR,PLT,PT,FIB,thromboplastin time (TT),D-d and FDP were prolonged in children with acute traumatic brain injury with different prognoses.Conclusion Coagulation dysfunctions exist in children after traumatic brain injury.The more serious the injury the more obvious abnormal blood coagulation and the worse the prognosis.Blood coagulation parameters provide rationales for evaluating prognoses and offering clinical interventions as soon as possible.
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Memo
收稿日期:2021-8-12。
通讯作者:靳文,Email:jinwen1970@sina.com